non-repeated measures analysis of variance (anova)  (GraphPad Software Inc)

Journal:

Article Title: Subeffective doses of dexketoprofen trometamol enhance the potency and duration of fentanyl antinociception

doi: 10.1038/sj.bjp.0704491

Figure Lengend Snippet: (A) Pooled data of the antinociceptive effects obtained with cumulative i.v. administrations of the μ-opioid agonist fentanyl previous to (Fent 1) and after the administration of 40 μg kg−1 of the NSAID dexketoprofen trometamol (Fent 2). The diagram represents the percentage of reduction of SMU responses to noxious mechanical stimulation. The potency of fentanyl was enhanced 5 fold by the NSAID whereas the administration of dexketoprofen trometamol on its own did not induce any significant reduction of responses (see Figure 3). (B) Shows the reduction of responses induced by fentanyl in control experiments when tested twice after an interval of 1 h. No significant differences were observed in this case between the two tests performed (statistical comparison was performed using the one-way analysis of variance, ANOVA, for repeated measures with the non-parametric post-hoc Dunn test, *P<0.05, **P<0.01, ***P<0.001).

Article Snippet: Statistical analysis were performed using one-way analysis of variance (ANOVA) for repeated measures with the non-parametric post-hoc Dunn test (GraphPad-Prism and GraphPad-Instat for Windows) to calculate the significant level of results in dose-response curves, and the t -test for comparison of ED 50 s. All the experiments in this study were carried out in accordance with European Union legislation regarding the use of animals for experimental protocols and all efforts were made to reduce the number of animals used.

Techniques: Control, Comparison